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Vicodin is a prescription medication that combines hydrocodone, an opioid pain reliever, with acetaminophen, a non-opioid pain reliever. This combination drug is used to manage moderate to severe pain in cases where other pain medications have proven ineffective. Hydrocodone works by binding to opioid receptors in the brain and spinal cord, altering the body's perception of pain. Acetaminophen, on the other hand, helps to reduce fever and relieve pain by inhibiting the production of certain chemicals in the brain that cause pain and inflammation.