Moderate to severe pain can be reduced with TAPENTADOL. Pain is an unpleasant emotional and sensory experience brought on by actual or possible tissue damage. TAPENTADOL, which is made up of Tapentadol, works directly on opioid receptors in the central nervous system to interfere with the transmission of pain signals from the brain to the body, hence lowering pain perception. TAPENTADOL should only be taken as directed by a physician. TAPENTADOL may cause constipation, headache, dizziness, nausea, drowsiness, vomiting, and abdominal discomfort, among other frequent adverse effects. Inform your physician if any of these symptoms worsen or continue.